Dendritic spines: from structure to in vivo function
نویسندگان
چکیده
منابع مشابه
Dendritic spines: from structure to in vivo function.
Dendritic spines arise as small protrusions from the dendritic shaft of various types of neuron and receive inputs from excitatory axons. Ever since dendritic spines were first described in the nineteenth century, questions about their function have spawned many hypotheses. In this review, we introduce understanding of the structural and biochemical properties of dendritic spines with emphasis ...
متن کاملEditorial: Dendritic spines: from shape to function†
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Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity. Numerous brain disorders are associated with abnormal dendritic spines. Spine formation, plasticity, and maintenance depend on synaptic activity and can be modulated by sens...
متن کامل[Structure-stability-function relationships of dendritic spines].
Dendritic spines, which receive most of the excitatory synaptic input in the cerebral cortex, are heterogeneous with regard to their structure, stability and function. Spines with large heads are stable, express large numbers of AMPA-type glutamate receptors, and contribute to strong synaptic connections. By contrast, spines with small heads are motile and unstable and contribute to weak or sil...
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The recent use of novel high-resolution imaging methods of living neurons in vitro has led to a change in the view of the dendritic spine, from a stable, long-term memory storage device to that of a dynamic structure, which can undergo fast morphological changes over periods of hours and even minutes. While the functional significance of these changes in spine dimensions is still obscure, we ha...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2012
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2012.102